Conditions Associated with Increased Eosinophils

There are many disorders where eosinophils have been found elevated in the blood or in different tissues. Given below are general categories of disease with examples of those that have increased levels of eosinophils.

 

Allergic Disorders

 
Allergic disorders are classically characterized by the presence of eosinophils. Allergic rhinoconjunctivitis (hay fever) has increased levels of eosinophils in the nasal mucosa. Asthma, after an exacerbation, shows increased numbers of eosinophils in the lung.
 

Drug Reactions 

 
Any drug/medicine has the potential to cause a reaction. Some of these reactions are allergic in nature, and eosinophils might be elevated in blood or in tissues where the drug is concentrated.
 

Infectious Diseases

 
Parasitic infections (Helminthiasis-worms), fungal infections, and some other types of infections are associated with increased numbers of eosinophils.
 

Blood Disorders

 
Hematologic disorders with increased levels of eosinophils include hypereosinophilic syndrome, leukemias, lymphomas, tumors, mastocytosis, and atheroembolic disease.
 

Immunologic Disorders and Reactions

 
Hyper-IgE syndrome, Ommen's syndrome, thymomas, and transplant rejections are only a few types of conditions with increased numbers of eosinophils.
 

Endocrine Disorders

 
Hypoadrenalism has been associated with increases in the levels of eosinophils in the blood. Specific Organ Involvement Below are certain conditions where eosinophils have been found to be increased or pathologically present. These examples are organized by the affected organs/tissues.
 

Skin and Subcutaneous Disorders
 

Atopic dermatitis (eczema), bullous pemphigoid, pemphigus vulgaris, dermatitis herpetiformis, drug-induced lesions, urticaria, eosinophilic panniculitis, angioedema with eosinophilia, Kimura's disease, Shulman's syndrome, Well's syndrome, eosinophilic ulcer of the oral mucosa, eosinophilic pustular folliculitis, and recurrent cutaneous necrotizing eosinophilic vaculitis.
 

Pulmonary Conditions
 

Drug/toxin-induced eosinophilic lung disease, Loeffler's syndrome, allergic bronchopulmonary aspergillosis, eosinophilic pneumonia, Churg-Strauss syndrome, eosinophilic granuloma, and pleural eosinophilia.
 

Gastrointestinal Diseases

 
Gastroesophageal reflux, parasitic infections, fungal infections, Helicobacter pylori infections, inflammatory bowel disease (ulcerative colitis and Crohn's disease), food allergic disorders, protein-induced enteropathy and protein-induced enterocolitis, allergic colitis, celiac disease, pimphigus vegtans (MR) and primary eosinophilic esophagitis, gastroenteritis, and colitis. Rare tumors (leiomyomatosis), connective tissue disorders, and vasculitic disorders.
 

Neurologic Disorders

 
Organizing chronic subdural hematoma membranes, central nervous system infections, ventriculoperitoneal shunts, and drug-induced adverse reactions.
 

Rheumatologic Illnesses

 
Organizing chronic subdural hematoma membranes, central nervous system infections, ventriculoperitoneal shunts, and drug-induced adverse reactions.
 

Cardiac Conditions

 
Secondary to systemic disorders such as the hypereosinophilic syndrome or the Churg-Strauss syndrome, heart damage has been reported. Certain congenital heart conditions (septal defects, aortic stenosis) are associated with increased levels of eosinophils in the blood.
 

Renal Diseases
 

Eosinophiluria (eosinophils in the urine) is associated with infections or interstitial nephritis and eosinophilic cystitis.

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