Research Publications

 
 
Physicians and researchers who study eosinophils publish their findings on a regular basis. The following list is a small subset of these articles for those seeking more information about research of eosinophilic disorders. REGID does not endorse or critique their contents. For a more exhaustive list, see the PubMed results for eosinophilic esophagitis.  
 
 

2012

 
Hommel KA, Franciosi JP, Hente EA, Ahrens A, Rothenberg ME. Treatment adherence in pediatric eosinophilic gastrointestinal disordersJ Pediatr Psychol. [Epub ahead of print].
 
Franciosi JP, Hommel KA, Debrosse CW, Greenberg AB, Greenler AJ, Abonia JP, Rothenberg ME, Varni JW.Quality of life in paediatric eosinophilic oesophagitis: what is important to patients? Child Care Health Dev.  [Epub ahead of print].
 
Spergel JM, Rothenberg ME, Collins MH, Furuta GT, Markowitz JE, Fuchs G 3rd, O'Gorman MA, Abonia JP, Young J, Henkel T, Wilkins JH, Liacouras CA. Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol. 2012;129(2):456-463.e3.
 
Wen T, Mingler MK, Blanchard C, Wahl B, Pabst O, Rothenberg ME. The Pan-B Cell Marker CD22 is Expressed on Gastrointestinal Eosinophils and Negativesly Regulates Tissue Eosinophilia. J Immunol. 2012;188(3):1075-82.
 
Abonia JP, Rothenberg ME. Eosinophilic esophagitis: rapidly advancing insightsAnnu Rev Med. 2012; 18(63):421-34.
 
 

2011

 
Franciosi JP, Hommel KA, Debrosse CW, Greenberg AB, Greenler AJ, Abonia JP, Rothenberg ME, Varni JW. Development of a validated patient-reported symptom metric for pediatric eosinophilic esophagitis: qualitative methods. BMC Gastroenterol. 2011;11:126. 
 
Lacy P, Willetts L, Kim JD, Lo AN, Lam B, Maclean El, Moqbel R, Rothenberg ME, Zimmermann N. Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on rac2. Int Arch Allergy Immunol. 2011;156(2):137-147.
 
Waddell A, Ahrens R, Steinbrecher K, Donovan B, Rothenberg ME, Munitz A, Hogan SP. Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11. J Immunol. 2011;186(10):5993-6003. 
 
Debrosse CW, Franciosi JP, King EC, Buckmeier Butz BK, Greenberg AB, Collins MH, Abonia JP, Assa'ad A, Putname PE, Rothenberg ME. Long-term outcomes in pediatric-onset esophageal eosinophilia. J Allergy Clin Immunol. 2011;128(1):132-8.
 
Sherrill JD, Rothenberg ME. Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies. J Allergy Clin Immunol. 2011;128(1):23-32; quiz 33-4.
 
Liacouras CA, Furuta GT, Hirano I, Atkins D, Attwood SE, Bonis PA, Burks AW, Chehade M, Collins MH, Dellon ES, Dohil R, Falk GW, Gonsalves N, Gupta SK, Katzka DA, Lucendo AJ, Markowitz JE, Noel RJ, Odze RD, Putnam PE, Richter JE, Romero Y, Ruchelli E, Sampson HA, Schoepfer A, Shaheen NJ, Sicherer SH, Spechler S, Spergel JM, Straumann A, Wershil BK, Rothenberg ME, Aceves SS. Eosinophilic esophagitis: Updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011;128(1):3-20.e6; quiz 21-2.
 
Eom CS, Park SM, Myung SK, Yun JM, Ahn JS. Use of acid-suppressive drugs and risk of fracture: a meta-analysis of observational studies. Ann Fam Med. 2011;9(3):257-67.
 
Eosinophilic Esophagitis by Dr. Glenn Furuta. Reprinted from Food Allergy News, Vol. 20, No. 4, copyright 2011, The Food Allergy & Anaphylaxis Network (FAAN). Posted with permission. 
 
Lim EJ, Lu TX, Blanchard C, Rothenberg ME. Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CBP-mediated histone 3 acetylation. J Biol Chem. 2011; 286(15):13193-1304.
 
Mulder DJ, Justinich CJ. Understanding eosinophilic esophagitis: the cellular and molecular mechanisms of an emerging disease. Mucosal Immunol. 2011;4(2):139-47.
 
Blanchard C, Stucke EM, Rodriguez-Jimenez B, Burwinkel K, Collins MH, Ahrens A, Alexander ES, Butz BK, Jameson SC, Kaul A, Franciosi JP, Kushner JP, Putnam PE, Abonia JP, Rothenberg ME. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol. 2011;127(1):208-17, 217e.1-7. 
 
Miles MV, Putnam PE, Miles L, Tang PH, Degrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011;140(1):82-90.
 
Kwiatek MA, Hirano I, Kahrilas PJ, Rothe J, Luger D, Pandolfino JE. Mechanical properties of the esophagus in eosinophilic esophagitis. Gastroenterology. 2011;140(1):82-90. 
 
 

2010

 
Abonia JP, Franciosi JP, Rothenberg ME. TGF-beta1: Mediator of a feedback loop in eosinophilic esophagitis-or should we really say mastocytic esophagitis? J Allergy Clin Immunol. 2010 Dec;126(6):1205-7.
 
 
Cortina S, McGraw K, deAlarcon A, Ahrens A, Rothenberg ME, Drotar D. Psychological functioning of children and adolescents with eosinophil-associated gastrointestinal disorders. Children's Health Care. 2010;39(4):266-78.
 
 
Straumann A, Conus S, Degen L, Felder S, Kummer M, Engel H, Bussmann C, Beglinger C, Schoepfer A, Simon HU. Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis. Gastroenterology. 2010 Nov;139(5):1526-1537.e1.
 
Finkelman FD, Boyce JA, Vercelli D, Rothenberg ME. Key advances in mechanisms of asthma, allergy, and immunology in 2009. J Allergy Clin Immunol. 2010 Feb;125(2):312-8.
 
Munitz A, Cole ET, Waddell A, Groschwitz K, Ahrens R, Steinbrecher K, Willson T, Han X, Denson L, Rothenberg ME, Hogan SP.  Paired immunoglobulin-like Receptor B (PIR-B) Negatively Regulates Macrophage Activation in Experimental Colitis. Gastroenterology. 2010 Aug;139(2):530-41. 
 
Rayapudi M, Mavi P, Zhu X, Pandey AK, Abonia JP, Rothenberg ME, Mishra A. Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice. J Leukoc Biol. 2010 Aug;88(2):337-46.
 
Zhu X, Wang M, Mavi P, Rayapudi M, Pandey AK, Kaul A, Putnam PE, Rothenberg ME, Mishra A. Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice. Gastroenterology. 2010 Jul;139(1):182-93.e7.
 
Simon HU, Rothenberg ME, Bochner BS, Weller PF, Wardlaw AJ, Wechsler ME, Rosenwasser LJ, Roufosse F, Gleich GJ, Klion AD. Refining the definition of hypereosinophilic syndrome. J Allergy Clin Immunol. 2010 Jul;126(1):45-9.
 
Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa'ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul;126(1):160-165. 
 
DeBrosse CW, Collins MH, Buckmeier Butz BK, Allen CL, King EC, Assa'ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol. 2010 Jul;126(1):112-119. 
 
Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME. Involvement of mast cells in eosinophilic esophagitis. J Allergy Clin Immunol. 2010 Jul; 126(1):140-9. 
 
Simon D, Wardlaw A, Rothenberg, ME. Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract. J Allergy Clin Immunol. 2010 Jul; 126(1):3-13;quiz 14-5. 
 
Zuo L, Fulkerson PC, Finkelman FD, Mingler M, Fischetti CA, Blanchard C, Rothenberg, ME. IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R{alpha}2-inhibited pathway. J Immunol. 2010 Jul;185(1):660-9. 
 
Niese KA, Chiaramonte MG, Ellies LG, Rothenberg ME, Zimmermann N. The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis. Respir Res. 2010 Jun; 11(1):87.
 
Gao PS, Shimizu K, Grant AV, Rafaels N, Zhou LF, Hudson SA, Konno S, Zimmermann N, Araujo MI, Ponte EV, Cruz AA, Nishimura M, Su SN, Hizawa N, Beaty TH, Mathias RA, Rothenberg ME, Barnes KC, Bochner BS. Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma. Eur J Hum Genet. 2010 Jun;18(6):713-9. 
 
Rosenwasser LJ, Rothenberg ME. IL-5 pathway inhibition in the treatment of asthma and Churg-Strauss syndrome. J Allergy Clin Immunol. 2010 Jun;125(6):1245-6.
 
Herbert DR, Orekov T, Roloson A, Ilies M, Perkins C, O'Brien W, Cederbaum S, Christianson DW, Zimmermann N, Rothenberg ME, Finkelman FD. Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. J Immunol. 2010 Jun;184(11):6438-46. 
 
Caldwell JM, Blanchard C, Collins MH, Putnam PE, Kaul A, Aceves SS, Bouska CA, Rothenberg ME. Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin Immunol. 2010;125(4):879-88 e8.
  
Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol. 2010 Apr 1;184(7):4033-41. 
 
Ingerski LM, Modi AC, Hood KK, Pai AL, Zeller M, Piazza-Waggoner C, Driscoll KA, Rothenberg ME, Franciosi J, Hommel KA.  Health-related quality of life across pediatric chronic conditions.  J Pediatr. 2010 Apr;156(4):639-44.
 
Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Frackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010 Apr;42(4):289-91.
 
Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, Putnam PE, Abonia JP, Santos J, Rothenberg ME. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010 Jan;59(1):12-20. 
 
Krarup AL, Villadsen GE, Mejlgaard E, Olesen SS, Drewes AM, Funch-Jensen P. Acid hypersensitivity in patients with eosinophilic oesophagitis. Scand J Gastroenterol. 2010 Mar;45(3):273-281. This is an interesting manuscript that demonstrates that the esophagus of EE patients is hypersensitive to acid exposure (as measured by time to heartburn).  Importantly, there is no differences in response to mechanical, thermal or electrical stimulation (markers of CNS sensitization), showing specificity of the response to acid. These results, combined with the recent findings that acid can increase eotaxin-3 release (Blanchard et al J Immunol; 2010;184:4033-41.), highlight the contribution of acid (reflux-associated acid or physiological acid) to EE. Based on this, the need to continue acid suppressive therapy in EE patients (regardless of GERD) should be considered.
 

2009

 

Putnam PE, Rothenberg ME. Eosinophilic esophagitis: concepts, controversies, and evidence. Curr Gastroenterol Rep. 2009 Jun;11(3):220-5.
 
Franciosi JP, Tam V, Liacouras CA, Spergel JM. A case-control study of sociodemographic and geographic characteristics of 335 children with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2009 Apr;7(4):415-9.
 
Qu Z, Kundu UR, Abadeer RA, Wanger A. Strongyloides colitis is a lethal mimic of ulcerative colitis: the key morphologic differential diagnosis. Hum Pathol. 2009 Apr;40(4):572-7. This article draws attention to the possibility that strongyloides infection can cause secondary eosinophilic colitis and should thus be in the differential diagnosis of EGID.
  
Franciosi JP, Liacouras CA.  Eosinophilic esophagitis.  Immunol Allergy Clin North Am. 2009 Feb;29(1):19-27, viii. Review.
 
Spergel JM, Brown-Whitehorn TF, Beausoleil JL, Franciosi J, Shuker M, Verma R, Liacouras CA. 14 years of eosinophilic esophagitis: clinical features and prognosis.  J Pediatr Gastroenterol Nutr. 2009 Jan;48(1):30-6.
 
Brandt EB, Munitz A, Orekov T, Mingler MK, McBride M, Finkelman FD, Rothenberg ME. Targeting IL-4/IL-13 Signaling to Alleviate Oral Allergen-induced Diarrhea. J Allergy Clin Immunol. 2009 Jan;123(1):53-8.
 

 

2008

 
Richard Kirsch, Karel Geboes, Neil A. Shepherd, Gert de Hertogh, Nando Di Nicola, Sylvie Lebel, Ugnius Mickys, Robert H.Ridell. Systemic mastocytosis involving the gastrointestinal tract: clinicopathologic and molecular study of five cases. Mod Pathol. 2008 Dec;21(12):1508-16.
 
Debrosse CW, Rothenberg ME. Allergy and Eosinophil-Associated Gastrointestinal Disorders (EGID). Curr Opin Immunol. 2008 Dec;20(6):703-8.
 
Ahrens R, Waddell A, Seidu L, Blanchard C, Carey R, Forbes E, Lampinen M, Wilson T, Cohen E, Stringer K, Ballard E, Munitz A, Xu H, Lee N, Lee JJ, Rothenberg ME, Denson L, Hogan SP. Intestinal Macrophage/Epithelial Cell-derived CCL11/eotaxin-1 Mediates Eosinophil Recruitment and Function in Pediatric Ulcerative Colitis. J Immunol. 2008 Nov 15;181(10):7390-9.
 
Yamada Y, Sanchez-Aguilera A, Brandt EB, McBride M, Al-Moamen NJ, Finkelman FD, Williams DA, Cancelas JA, Rothenberg ME. FIP1L1/PDGFRalpha Synergizes with SCF to Induce Systemic Mastocytosis in a Murine Model of Chronic Eosinophilic Leukemia/Hypereosinophilic Syndrome. Blood. 2008 Sep 15;112(6):2500-7.
 
Zimmermann N, McBride ML, Yamada Y, Hudson SA, Jones C, Cromie KD, Crocker PR, Rothenberg ME, Bochner BS. Siglec-F Antibody Administration to Mice Selectively Reduces Blood and Tissue Eosinophils. Allergy. 2008 Sep;63(9):1156-63.
 
Munitz A, McBride ML, Bernstein JS, Rothenberg ME. A Dual Activation and Inhibition Role for the Paired Immunoglobulin-like Receptor B in EosinophilsBlood. 2008 Jun 15;111(12):5694-703.
 
Fulkerson PC, Rothenberg ME. Origin, Regulation and Physiological Function of Intestinal Eosinophils. Best Pract Res Clin Gastroenterol. 2008 Jun;22(3):411-23. Review.
 
Stein ML, Villanueva JM, Buckmeier BK, Yamada Y, Filipovich AH, Assa'ad AH, Rothenberg ME. Anti-IL-5 (Mepolizumab) Therapy Reduces Eosinophil Activation Ex Vivo and Increases IL-5 and IL-5 Receptor Levels.  J Allergy Clin Immunol. 2008 Jun;121(6):1473-83, 1483.e1-4.
 
Collins MH, Blanchard C, Abonia JP, Kirby C, Akers R, Wang N, Putnam PE, Jameson SC, Assa'ad AH, Konikoff MR, Stringer KF, Rothenberg ME. Clinical, Pathologic, and Molecular Characterization of Familial Eosinophilic Esophagitis Compared with Sporadic Cases.  Clin Gastroenterol Hepatol. 2008 Jun;6(6):621-9.
 
Forbes EE, Groschwitz K, Abonia JP, Brandt EB, Cohen E, Blanchard C, Ahrens R, Seidu L, McKenzie A, Strait R, Finkelman FD, Foster PS, Matthaei KI, Rothenberg ME, Hogan SP. IL-9- and Mast Cell-Mediated Intestinal Permeability Predisposes to Oral Antigen Hypersensitivity.  J Exp Med. 2008 Apr 14;205(4):897-913.
 
Rothenberg ME, Klion AD, Roufosse FE, Kahn JE, Weller PF, Simon HU, Schwartz LB, Rosenwasser LJ, Ring J, Griffin EF, Haig AE, Frewer PIH, Parkin JM, Gleich GJ, for the Mepolizumab HES Study Group. Treatment of Patients with the Hypereosinophilic Syndrome with Mepolizumab. N Engl J Med. 2008 Mar; 358:1215-28.
 
Balatsinou C, Milano A, Caldarella MP, Laterza F, Pierdomenico SD, Cuccurullo F, Neri M: Eosinophilic esophagitis is a component of the anticonvulsant hypersensitivity syndrome: Description of two casesDigestive and Liver Disease. 2008 Feb;40(2):145-148. 
 
Gastrointestinal Endoscopy Clinics: Eosinophilic Esophagitis. Edited by G.T. Furuta. 2008 Jan;18(1):1-224.
 

 

2007

 
Furuta GT, Liacouras CA, Collins MH, Gupta SK, Justinich C, Putnam PE, Bonis P, Hassall E, Straumann A, Rothenberg ME, Members of the First International Gastrointestinal Eosinophil Research Symposium (FIGERS) Subcommittees. Eosinophilic Esophagitis in Children and Adults: A Systematic Review and Consensus Recommendations for Diagnosis and Treatment. Gastroenterology. 2007 Oct;133(4):1342-63. 
 
Zuo L, Rothenberg ME. Gastrointestinal eosinophilia. Immunol Allergy Clin North Am. 2007 Aug;27(3):443-55.
 
Liacouras CA, Bonis P, Putnam PE, Straumann A, Ruchelli E, Gupta SK, Lee JJ, Hogan SP, Wershil BK, Rothenberg ME, Ackerman SJ, Gomes I, Murch S, Mishra A, Furuta GT. Summary of the first international gastrointestinal eosinophil research symposium. J Pediatr Gastroenterol Nutr. 2007 Sep;45(3):370-91. 
 
Foroughi S, Foster B, Kim N, Bernardino LB, Scott LM, Hamilton RG, Metcalfe DD, Mannon PJ, Prussin C. Anti-IgE treatment of eosinophil-associated gastrointestinal disorders. J Allergy Clin Immunol. 2007 Sep;120(3):594-601.
 
Vanderheyden AD, Petras RE, DeYoung BR, Mitros, FA. Emerging Eosinophilic (Allergic) Esophagitis: Increased Incidence or Increased Recognition? Arch Pathol Lab Med. 2007 May;131(5):777-9. 
 
Lucendo AJ, Castillo P, Martín-Chávarri S, Carrión G, Pajares R, Pascual JM, Manceñido N, Erdozain JC. Manometric findings in adult eosinophilic oesophagitis: a study of 12 cases. Eur J Gastroenterol Hepatol. 2007 May;19(5):417-24.
 
Lucendo A, Navarro M, Comas C, Pascual J, Burgos E, Santamarı´a L, Larrauri J. Immunophenotypic Characterization and Quantification of the Epithelial Inflammatory Infiltrate in Eosinophilic Esophagitis Through Stereology: An Analysis of the Cellular Mechanisms of the Disease and the Immunologic Capacity of the Esophagus. Am J Surg Pathol. 2007 Apr;31(4):598-606. 
 
Aceves S, Newbury R, Dohil R, Bastian J, Broide D. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2007 Jan;119(1):206-12. 
 
Kirsch R, Bokhary R, Marcon M, Cutz E. Activated Mucosal Mast Cells Differentiate Eosinophilic (Allergic) Esophagitis From Gastroesophageal Reflux Disease. J Pediatr Gastroenterol Nutr. 2007 Jan;44(1):20-26.
 

 

2006

 
Konikoff MR, Noel RJ, Blanchard C, Kirby C, Jameson SC, Buckmeier BK, Akers R, Cohen MB, Collins MH, Assa'ad AH, Aceves SS, Putnam PE, Rothenberg ME. A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis. Gastroenterology. 2006 Nov;131(5): 1381-91.
 
Furuta, G. Eructations From Eosinophils. Gastroenterology. 2006 Nov;131(5):1629-31.
 
Boyer D, Vargas SO, Slattery D, Rivera-Sanchez YM, Colin AA. Churg-Strauss syndrome in children: a clinical and pathologic review. Pediatrics. 2006 Sep;118(3):e914-20.
 
Fulkerson PC, Fischetti CA, Hassman LM, Nikolaidis NM, Rothenberg ME. Persistent Effects Induced by IL-13 in the Lung. Am J Respir Cell Mol Biol. 2006 Sep;35(3):337-46. 
 
Forbes E, Hulett M, Ahrens R, Wagner N, Smart V, Matthaei KI, Brandt EB, Dent LA, Rothenberg ME, Tang M, Foster PS, Hogan SP. ICAM-1-dependent pathways regulate colonic eosinophilic inflammation. J Leukoc Biol. 2006 Aug;80(2):330-41. 
 
Hogan SP, Seidu L, Blanchard C, Groschwitz K, Mishra A, Karow ML, Ahrens R, Artis D, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rothenberg ME. Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J Allergy Clin Immunol. 2006 Jul;118(1):257-68.
 
Munitz A, Bachelet I, Eliashar R, Khodoun M, Finkelman FD, Rothenberg ME, Levi-Schaffer F. CD48 is an allergen and IL-3-induced activation molecule on eosinophils. J Immunol. 2006 Jul 1;177(1):77-83.
 
Rothenberg ME, Hogan SP. The Eosinophil. Annu Rev Immunol. 2006;24:147-74. Review.
 
Brandt EB, Zimmermann N, Muntel EE, Yamada Y, Pope SM, Mishra A, Hogan SP, Rothenberg ME. The alpha4bbeta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine.  Clin Exp Allergy. 2006 Apr;36(4):543-53.
 
Hogan SP, Rothenberg ME. Eosinophil Function in Eosinophil-Associated Gastrointestinal Disorders. Curr Allergy Asthma Rep. 2006 Feb;6(1):65-71. 
 
Yamada Y, Rothenberg ME, Lee AW, Akei HS, Brandt EB, Williams DA, Cancelas JA. The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES) / chronic eosinophilic leukemia (CEL)-like disease. Blood. 2006 May 15;107(10):4071-9. 
 
Katzka, David A. Eosinophilic esophagitis. Current Opinion in Gastroenterology. 2006 Jul;22(4):429-432. 
 
Klion A, Bochner B, Gleich G, Nutman T, Rothenberg M, Simon H-U, Wechsler M, Weller P, the Hypereosinophilic Syndromes Working Group: Approaches to the Treatment of Hypereosinophilic Syndromes: A Workshop Summary Report. J Allergy Clin Immunol. 2006 Jun; 117(6):1292-1302.
 
Blanchard C, Wang N, Stringer KF, Mishra A, Fulkerson PC, Abonia JP, Jameson SC, Kirby C, Konikoff MR, Collins MH, Cohen MB, Akers R, Hogan SP, Assa'ad AH, Putnam PE, Aronow BJ, Rothenberg ME. Eotaxin-3 and a Uniquely Conserved Gene-Expression Profile in Eosinophilic Esophagitis. J Clin Invest. 2006 Feb;116(2):536-547.
De Angelis P, Markowitz JE, Torroni F, Caldaro T, Pane A, Morino G, Sforza Wietrzykowska R, Federici di Abriola G, Ponticelli A, Dall'oglio L. Paediatric eosinophilic oesophagitis: Towards early diagnosis and best treatment. Dig Liver Dis. 2006 Apr;38(4):245-51. 

 

2005

 
Noel RJ, Rothenberg ME. Eosinophilic Esophagitis. Curr Opin Pediatr. 2005 Dec;17(6):690-4.
 
Ngo P, Furuta GT. Treatment of Eosinophilic Esophagitis in Children. Curr Treat Options Gastroenterol. 2005 Oct;8(5):397-403.
 
Akei HS, Mishra A, Blanchard C, Rothenberg ME. Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice. Gastroenterology. 2005 Sep;129(3):985-94.
 
Aceves SS, Dohil R, Newbury RO, Bastian JF. Topical viscous budesonide suspension for treatment of eosinophilic esophagitis. J Allergy Clin Immunol. 2005 Sep;116(3):705-6.
 
Blanchard C, Mishra A, Saito-Akei H, Monk P, Anderson I, Rothenberg ME. Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354). Clin Exp Allergy. 2005 Aug;35(8):1096-103.
 
Zimmerman SL, Levine MS, Rubesin SE, Mitre MC, Furth EE, Laufer I, Katzka DA. Idiopathic eosinophilic esophagitis in adults: the ringed esophagus. Radiology. 2005 Jul;236(1):159-65. 
 
Meyer GW. Eosinophilic esophagitis in a father and a daughter. Gastrointest Endosc. 2005 Jun;61(7):932. 
 
Desai TK, Stecevic V, Chang CH, Goldstein NS, Badizadegan K, Furuta GT. Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc. 2005 Jun;61(7):795-801.
 
Spergel J, Rothenberg ME, Fogg M. Eliminating eosinophilic esophagitis. Clin Immunol. 2005 May;115(2):131-2. 
 
Simon D, Marti H, Heer P, Simon HU, Braathen LR, Straumann A. Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases. J Allergy Clin Immunol. 2005 May;115(5):1090-2. 
 
Lucendo Villarin AJ, Carrion Alonso G, Navarro Sanchez M, Martin Chavarri S, Gomez Senent S, Castillo Grau P, Pascual Turrion JM, Gonzalez Sanz-Agero P. Eosinophilic esophagitis in adults, an emerging cause of dysphagia. Description of 9 cases. Rev Esp Enferm Dig. 2005 Apr;97(4):229-39. English, Spanish.
 
Cantu P, Velio P, Prada A, Penagini R. Ringed oesophagus and idiopathic eosinophilic oesophagitis in adults: an association in two cases. Dig Liver Dis. 2005 Feb;37(2):129-34.
 
Straumann A, Simon HU. Eosinophilic esophagitis: escalating epidemiology? J Allergy Clin Immunol. 2005 Feb;115(2):418-9. 
 
Nostrant TT. Esophageal Dilation / Dilators. Curr Treat Options Gastroenterol. 2005 Feb;8(1):85-95.
 
Patel SM, Falchuk KR. Three brothers with dysphagia caused by eosinophilic esophagitis. Gastrointest Endosc. 2005 Jan;61(1):165-7. No Abstract Available.
 
Spergel JM, Brown-Whitehorn T. The use of patch testing in the diagnosis of food allergy. Curr Allergy Asthma Rep. 2005 Jan;5(1):86-90. Review. 
 
Mann NS, Leung JW. Pathogenesis of esophageal rings in eosinophilic esophagitis. Med Hypotheses. 2005;64(3):520-3. 
 

 

2004

 
Kukuruzovic RH, Elliott EE, O'Loughlin EV, Markowitz JE. Non-surgical interventions for eosinophilic oesophagitis. Cochrane Database Syst Rev. 2004;(3):CD004065. Review. 
 
Kim YJ, Prussin C, Martin B, Law MA, Haverty TP, Nutman TB, Klion AD. Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti-IL-5 antibody SCH55700. J Allergy Clin Immunol. 2004 Dec;114(6):1449-55. 
 
Hogan SP, Rothenberg ME. The eosinophil as a therapeutic target in gastrointestinal disease.  Aliment Pharmacol Ther. 2004 Dec;20(11-12):1231-40. Review. 
 
 
Higashi N, Mita H, Taniguchi M, Turikisawa N, Higashi A, Ozawa Y, Tohma S, Arimura K, Akiyama K. Urinary eicosanoid and tyrosine derivative concentrations in patients with vasculitides. J Allergy Clin Immunol. 2004 Dec;114(6):1353-8. 
 
Lucendo AJ, Carrion G, Navarro M, Pascual JM, Gonzalez P, Castillo P, Erdozain JC. Eosinophilic esophagitis in adults: an emerging disease. Dig Dis Sci. 2004 Nov-Dec;49(11-12):1884-8. 
 
Karthik SV, Casson DH. Bilateral atopic cataracts in a child with eosinophilic esophagitis: an association to look out for. J Pediatr Gastroenterol Nutr. 2004 Nov;39(5):557-9. No abstract available.
 
Wei L, MacDonald TM, Walker BR. Summaries for patients. Glucocorticoid medications and the risk for cardiovascular disease.  Ann Intern Med. 2004 Nov 16;141(10):I58. 
 
Sant'Anna AM, Rolland S, Fournet JC, Yazbeck S, Drouin E. Eosinophilic Esophagitis in Children: Symptoms, Histology and pH Probe Results. J Pediatr Gastroenterol Nutr. 2004 Oct;39(4):373-377. 
 
Liacouras CA, Ruchelli E. Eosinophilic esophagitis. Curr Opin Pediatr. 2004 Oct;16(5):560-6. Review.
 
Straumann A, Spichtin HP, Bucher KA, Heer P, Simon HU. Eosinophilic esophagitis: red on microscopy, white on endoscopy. Digestion. 2004;70(2):109-16. 
 
Garrett JK, Jameson SC, Thomson B, Collins MH, Wagoner LE, Freese DE, Boyce JA, Beck LA, Filipovich A, Villanueva JM, Sutton SA, Assa'ad AH, Rothenberg ME. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol, 2004; 113: 115-9. 
 
Noel RJ, Putnam PE, Rothenberg ME. Eosinophilic Esophagitis. N Engl J Med, 2004; 351(9):940-1. 
 
Noel RJ, Putnam PE, Collins MH, Assa'ad AH, Guajardo JR, Jameson SC, Rothenberg ME. Heterogeneous clinical and immunopathological responses to swallowed fluticasone propionate for eosinophilic esophagitis. Clin Gastroenterol Hepatol, 2004; 2:568-75. 
 
Dahms BB. Reflux esophagitis: sequelae and differential diagnosis in infants and children including eosinophilic esophagitis. Pediatr Dev Pathol. 2004 Jan-Feb;7(1):5-16. Review. 
 
Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol. 2004 Jan;113(1):11-28.
 

 

2003

 
Lack G, Fox D, Northstone K, Golding J. Factors associated with the development of peanut allergy in childhood.  N Engl J Med. 2003 Mar 13;348(11):977-85.
 
 
Leung DY, Sampson HA, Yunginger JW, Burks AW Jr, Schneider LC, Wortel CH, Davis FM, Hyun JD, Shanahan WR Jr. Effect of anti-IgE therapy in patients with peanut allergy. N Engl J Med. 2003 Mar 13;348(11):986-93.
 
 

 

2002

 
Furuta, GT. Eosinophilic esophagits: an emerging clinicopathologic entity. Curr Allergy Asthma Rep. 2002. Jan; 2(1):67-72 Review. 
 
Fox VL, Kurko S, Furuta GT. Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest Endosc. 2002 August;56(2):260-70. Abstract not available.
 
Teitelbaum JE, Fox VL, Twarog FJ, Nurko S, Antonioli D, Gleich G, Badizadegan K, Furuta GT. Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology. 2002 May; 122(5):1216-25. 
 
Guajardo JR, Plotnick LM, Fende JM, Collins MH, Putnam PE, Rothenberg ME. Eosinophil-associated gastrointestinal disorders: A world-wide-web based registry. J Pediatr. 2002 Oct;141(4):576-81. 
 

 

2001

 
Kokkonen J, Ruuska T, Karttunen TJ, Niinimaki A. Mucosal pathology of the foregut associated with food allergy and recurrent abdominal pains in children. Acta Paediatr. 2001 Jan;90(1):16-21.
 
Mishra A, Hogan SP, Brandt EB, Rothenberg ME. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest. 2001 Jan;107(1):83-90. 
 

 

2000

 
Orenstein SR, Shalaby TM, Di Lorenzo C, Putnam PE, Sigurdsson L, Kocoshis SA. The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am J Gastroenterol. 2000 Jun;95(6):1422-30.
 
Ahmad M, Soetikno RM, Ahmed A. The differential diagnosis of eosinophilic esophagitis. J Clin Gastroenterol. 2000 Apr;30(3):242-4.
 

 

1999

 

Liacouras CA, Markowitz JE. Eosinophilic esophagitis: A subset of eosinophilic gastroenteritis. Curr Gastroenterol Rep. 1999 Jun;1(3):253-8. 
 
 
Ruchelli E, Wenner W, Voytek T, Brown K, Liacouras C. Severity of esophageal eosinophilia predicts response to conventional gastroesophageal reflux therapy. Pediatr Dev Pathol. 1999 Jan-Feb;2(1):15-8. 
 

 

1998

 
Rothenberg ME. Eosinophilia. N Engl J Med. 1998; 338:1592-1600.
 
Liacouras CA, Wenner WJ, Brown K, Ruchelli E. Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids. J Pediatr Gastroenterol Nutr. 1998 Apr;26(4):380-5. 
 

 

1997

 
Liacouras CA. Failed Nissen fundoplication in two patients who had persistent vomiting and eosinophilic esophagitis. J Pediatr Surg. 1997 Oct;32(10):1504-6. 
 
 

1995

 
Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995 Nov;109(5):1503-12. 
 
Vitellas KM, Bennett WF, Bova JG, Johnson JC, Greenson JK, Caldwell JH. Radiographic manifestations of eosinophilic gastroenteritis.  Abdom Imaging. 1995 Sep-Oct;20(5):406-13.
 

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